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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFS
All Species:
38.48
Human Site:
Y153
Identified Species:
70.56
UniProt:
P49914
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49914
NP_006432.1
203
23256
Y153
L
G
R
G
K
G
Y
Y
D
A
Y
L
K
R
C
Chimpanzee
Pan troglodytes
XP_001154891
203
23207
Y153
L
G
R
G
K
G
Y
Y
D
A
Y
L
K
R
C
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_852666
203
23320
Y154
L
G
R
G
R
G
Y
Y
D
A
Y
L
R
R
C
Cat
Felis silvestris
Mouse
Mus musculus
Q9D110
203
23183
Y153
L
G
R
G
K
G
Y
Y
D
T
Y
L
K
R
C
Rat
Rattus norvegicus
NP_001009349
203
23222
Y153
L
G
R
G
K
G
Y
Y
D
T
Y
L
K
R
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516124
97
11478
H60
R
Y
K
F
Q
S
N
H
M
D
M
V
K
L
V
Chicken
Gallus gallus
XP_413857
210
23450
Y163
L
G
R
G
K
G
Y
Y
D
T
Y
L
G
R
C
Frog
Xenopus laevis
NP_001089249
205
23364
Y152
L
G
R
G
K
G
Y
Y
D
T
F
L
E
R
Y
Zebra Danio
Brachydanio rerio
XP_002662791
199
22883
Y152
L
G
R
G
K
G
F
Y
D
T
Y
L
E
R
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001097432
201
22863
Y152
M
G
H
G
M
G
Y
Y
D
K
F
L
K
Q
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9XWE6
206
23542
Y151
C
G
H
G
K
G
Y
Y
D
R
F
F
S
T
H
Sea Urchin
Strong. purpuratus
XP_001183516
161
18411
G124
N
R
C
V
E
E
T
G
V
K
P
V
T
I
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40099
211
24040
Y157
M
G
H
G
A
G
Y
Y
D
D
F
F
Q
R
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
N.A.
86.2
N.A.
83.2
83.2
N.A.
35.4
66.6
55.6
60
N.A.
35.9
N.A.
37.8
42.3
Protein Similarity:
100
100
N.A.
94.5
N.A.
92.6
93
N.A.
43.3
80.9
80.4
80.3
N.A.
59.1
N.A.
55.8
59.1
P-Site Identity:
100
100
N.A.
86.6
N.A.
93.3
93.3
N.A.
6.6
86.6
73.3
80
N.A.
53.3
N.A.
46.6
0
P-Site Similarity:
100
100
N.A.
100
N.A.
93.3
93.3
N.A.
33.3
86.6
86.6
93.3
N.A.
73.3
N.A.
53.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
51.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
0
0
24
0
0
0
0
8
% A
% Cys:
8
0
8
0
0
0
0
0
0
0
0
0
0
0
54
% C
% Asp:
0
0
0
0
0
0
0
0
85
16
0
0
0
0
0
% D
% Glu:
0
0
0
0
8
8
0
0
0
0
0
0
16
0
0
% E
% Phe:
0
0
0
8
0
0
8
0
0
0
31
16
0
0
0
% F
% Gly:
0
85
0
85
0
85
0
8
0
0
0
0
8
0
0
% G
% His:
0
0
24
0
0
0
0
8
0
0
0
0
0
0
16
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% I
% Lys:
0
0
8
0
62
0
0
0
0
16
0
0
47
0
0
% K
% Leu:
62
0
0
0
0
0
0
0
0
0
0
70
0
8
0
% L
% Met:
16
0
0
0
8
0
0
0
8
0
8
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% P
% Gln:
0
0
0
0
8
0
0
0
0
0
0
0
8
8
0
% Q
% Arg:
8
8
62
0
8
0
0
0
0
8
0
0
8
70
0
% R
% Ser:
0
0
0
0
0
8
0
0
0
0
0
0
8
0
0
% S
% Thr:
0
0
0
0
0
0
8
0
0
39
0
0
8
8
0
% T
% Val:
0
0
0
8
0
0
0
0
8
0
0
16
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
77
85
0
0
54
0
0
0
16
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _